Carboplatin Dose Calculator (Calvert Formula)
Calculate a carboplatin chemotherapy dose with the Calvert formula. Enter the target AUC and the patient's GFR (or creatinine clearance), and this calculator returns the total dose in milligrams: dose = AUC × (GFR + 25).
Rates and fees change frequently. Always confirm the current figures
with the official authority before relying on this result.
Formula
Dose (mg) = Target AUC × (GFR + 25)
- The Calvert formula sets carboplatin dose from a target exposure (AUC) rather than body surface area.
- Dose (mg) = AUC × (GFR + 25), where GFR is in mL/min and the +25 represents non-renal clearance.
- Target AUC is usually 5–7 mg/mL·min depending on the regimen and whether other drugs are combined.
- GFR is often estimated from creatinine clearance (e.g. Cockcroft-Gault); many centres cap it (e.g. at 125 mL/min) to avoid overdosing.
- Because dosing depends on AUC, the total milligrams don't change with body surface area.
- This is an educational tool — actual chemotherapy dosing must be done and checked by qualified oncology staff.
AUC 5, GFR 60 mL/min
Inputs
- Target AUC: 5 mg/mL·min
- GFR / CrCl: 60 mL/min
Dose = 5 × (60 + 25) = 5 × 85 = 425 mg of carboplatin.
Frequently asked questions
What is the Calvert formula?
It's the standard way to dose carboplatin from a target AUC: dose (mg) = AUC × (GFR + 25). This targets a consistent drug exposure across patients.
Why does the formula add 25 to GFR?
The +25 mL/min accounts for the non-renal clearance of carboplatin, so the dose reflects total clearance, not just kidney function.
Should I cap the GFR?
Many guidelines cap estimated GFR (commonly at 125 mL/min) because overestimated renal function can lead to an excessive dose. Follow your local protocol.
Is this safe to use for treatment?
No — it's for education and quick estimation. Real carboplatin dosing must be calculated, verified, and administered by trained oncology professionals.